GUCY1A1-LDHA Axis Suppresses Ferroptosis in Cardiac Ischemia-Reperfusion Injury
These findings indicate that the compromise of the sGC-cGMP-PKG pathway is associated with reduced phosphorylation of LDHA and GPX4, and that GUCY1A1 activation may be considered as a strategy to alleviate endothelial ferroptosis and cardiac microvascular reperfusion injury.
Authors
- Y H Li (ORCID: https://orcid.org/0000-0001-8085-9437)
- Li Su (ORCID: https://orcid.org/0000-0001-7264-9501)
- Muyin Liu (ORCID: https://orcid.org/0000-0002-9954-4467)
- Juying Qian (ORCID: https://orcid.org/0000-0002-7512-3692)
- Weida Qiu (ORCID: https://orcid.org/0000-0003-2206-8439)
- Ming Yin (ORCID: https://orcid.org/0000-0002-8905-5467)
- Wentao Zhu (ORCID: https://orcid.org/0000-0002-1123-2777)
- Junbo Ge (ORCID: https://orcid.org/0000-0002-9360-7332)
- You Zhou (ORCID: https://orcid.org/0000-0001-9250-0982)
- Chenguang Li (ORCID: https://orcid.org/0000-0002-5287-5269)
- Jinxiang Chen (ORCID: https://orcid.org/0000-0002-2323-3531)
- Zhangwei Chen (ORCID: https://orcid.org/0000-0003-3223-5261)
- Yuqiong Chen (ORCID: https://orcid.org/0000-0001-7592-5989)
- Qiyu Li (ORCID: https://orcid.org/0009-0002-7308-1334)
- Danbo Lu (ORCID: https://orcid.org/0000-0003-4753-335X)
Institutions
- Fudan University (CN)
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1161/circresaha.124.326029
- Citations
- 7
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 5.64