Defining the cell and molecular origins of the primate ovarian reserve

The primate ovarian reserve is established during late fetal development and consists of quiescent primordial follicles in the ovarian cortex each composed of granulosa cells surrounding an oocyte in dictate. As late stages of fetal development are not routinely accessible using human tissues, the current study exploits the evolutionary proximity of the rhesus macaque to investigate follicle formation in primates. Like in humans, the rhesus prenatal ovary develops multiple types of pre-granulosa cells in time and space, with primordial follicles deriving from later emerging pre-granulosa subtypes. In addition, our work shows that activated medullary follicles recruit fetal theca cells to establish a two-cell system for sex-steroid hormone production prior to birth, providing a cell-based explanation for mini puberty.

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Publication Details

Journal
Nature Communications
Published
2025-08-26
DOI
https://doi.org/10.1038/s41467-025-62702-0
Citations
2
Primary Topic
Reproductive Biology and Fertility
Type
article
Field-Weighted Citation Impact
3.76
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article

Defining the cell and molecular origins of the primate ovarian reserve

Amanda Mackie, Fei‐Man Hsu, Jon D. Hennebold, Ernesto J. Rojas et al.
2 citations
Nature Communications
Reproductive Biology and Fertility
3.76
article

Defining the cell and molecular origins of the primate ovarian reserve

Amanda Mackie, Fei‐Man Hsu, Jon D. Hennebold, Ernesto J. Rojas, Enrique Sosa, Sissy E. Wamaitha, Amander T. Clark, Diana J. Laird, Francesco Monticolo, Jian Shu, Melinda Murphy, Kiana Oyama, Maggie Custer
article en
2 citations

Abstract

The primate ovarian reserve is established during late fetal development and consists of quiescent primordial follicles in the ovarian cortex each composed of granulosa cells surrounding an oocyte in dictate. As late stages of fetal development are not routinely accessible using human tissues, the current study exploits the evolutionary proximity of the rhesus macaque to investigate follicle formation in primates. Like in humans, the rhesus prenatal ovary develops multiple types of pre-granulosa cells in time and space, with primordial follicles deriving from later emerging pre-granulosa subtypes. In addition, our work shows that activated medullary follicles recruit fetal theca cells to establish a two-cell system for sex-steroid hormone production prior to birth, providing a cell-based explanation for mini puberty.

Nature CommunicationsVol. 16(1)
Oregon National Primate Research Center (US), Broad Institute (US), Harvard University (US), University of California, Los Angeles (US), Oregon Health & Science University (US), University of California, San Francisco (US), Massachusetts General Hospital (US), Reproductive Science Center (US), Broad Center (US)
Openalex Percentile: Top 6%
Reproductive Biology and Fertility
3.76
DOIOpen Access PDFOpenAlex
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Defining the cell and molecular origins of the primate ovarian reserve — Amanda Mackie, Fei‐Man Hsu, et al. · Nature Communications (2025) | TGRS Research Map | TGRS