Genomic Analysis of Cardiovascular Diseases Utilizing Space Omics and Medical Atlas
Short-duration spaceflight induces significant gene expression changes that are relevant to cardiovascular disease risk. These changes are mediated largely through immune signaling and transcriptional regulation in peripheral blood mononuclear cells. Findings highlight the need for tailored countermeasures and longitudinal monitoring in future long-duration missions.
Authors
- Cem Meydan (ORCID: https://orcid.org/0000-0002-0663-6216)
- J. R. Shah (ORCID: https://orcid.org/0009-0004-3088-7543)
- M. Windy McNerney (ORCID: https://orcid.org/0000-0002-6536-5671)
- Joshua Ong (ORCID: https://orcid.org/0000-0003-4860-827X)
- Ryung Lee (ORCID: https://orcid.org/0000-0002-8365-5672)
- JangKeun Kim (ORCID: https://orcid.org/0000-0002-8733-9925)
- Ethan Waisberg (ORCID: https://orcid.org/0000-0001-8999-0212)
- Afshin Beheshti (ORCID: https://orcid.org/0000-0003-4643-531X)
- Christopher E. Mason (ORCID: https://orcid.org/0000-0002-1850-1642)
- Rahul Kumar (ORCID: https://orcid.org/0000-0001-8574-2895)
- Kyle Sporn (ORCID: https://orcid.org/0009-0005-5707-9009)
- Abir Rayhun
- Jacques Calixte (ORCID: https://orcid.org/0009-0005-1654-8913)
Institutions
- Broad Institute (US)
- Albert Einstein College of Medicine (US)
- University of Massachusetts Chan Medical School (US)
- VA Palo Alto Health Care System (US)
- Cornell University (US)
- University of Cambridge (GB)
- University of Michigan (US)
- Jacobs Institute (US)
- McGowan Institute for Regenerative Medicine (US)
- Weill Cornell Medicine (US)
- Syracuse University (US)
- Columbia University (US)
- Stanford University (US)
Publication Details
- Journal
- Genes
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3390/genes16090996
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00