Glutamate to GABA ratio is elevated in patients with IDH-mutant lower-grade gliomas and seizures
Glioma patients with seizures have an altered balance of Glx and GABA in tumor/peritumoral tissue, supporting the hypothesis that neurotransmitter imbalances contribute to seizure activity. <sup>1</sup>H-MRS may provide non-invasive biomarkers for identifying neurotransmitter dysregulation in glioma-related epilepsy.
Authors
- Alberto Bizzi (ORCID: https://orcid.org/0000-0002-0253-5274)
- Peter B. Barker (ORCID: https://orcid.org/0000-0002-6410-7793)
- Jianwei Xiang
- Riccardo Pascuzzo (ORCID: https://orcid.org/0000-0001-6555-1784)
- Ruben Gianeri (ORCID: https://orcid.org/0000-0002-1728-2070)
- Alessia Pellerino (ORCID: https://orcid.org/0000-0003-3243-0059)
- Luigi Antelmi (ORCID: https://orcid.org/0000-0002-4173-5412)
- Riccardo Soffietti (ORCID: https://orcid.org/0000-0002-9204-7038)
- Roberta Rudà (ORCID: https://orcid.org/0000-0001-9134-1537)
- Francesca Mo (ORCID: https://orcid.org/0000-0002-8469-7567)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Turin (IT)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf155
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- U.S. Department of Defense
- Ministero della Salute
- National Institutes of Health