A Synthesis, spectral and biological evaluation of in vitro antimicrobial activity and molecular docking studies of Schiff base ligand 1,2-cyclohexadiene/O-vanillin and its transition metal complexes

Exploring application of cost-effective transition metal-based drugs with high pharmaceutical properties has led to the progression of Schiff-base centred medicinal chemistry. Following this line, herein a series of new class of transition metal complexes Ni(II), Cd(II),Mn (II) and Zn(II) have been synthesized using a Schiff base ligand derived from 2 mole of o-vanillin and 1 mole of 1,2-cyclohexanediamine. The elemental analysis, conductivity, proton NMR, UV-Vis, IR, spectral studies, and TGA studies were used to characterize the as-synthesized ligand together with associated metal complexes. Additionally, testing the antimicrobial properties against gram-positive (S. aureus) and gram-negative (E. coli) bacteria establishes a higher inhibiting efficiency and highpoints the role of the compounds in stronger antibiotic use action; as a result, the current study acknowledges the potential of the new Schiff-base derived complexes as a prescription medication.