Cerebral small vessel disease as a possibly immune-related adverse event of immunotherapy in lung cancer patients: a retrospective study
This study found that CSVD may be a related adverse event of immunotherapy in lung cancer patients. In addition to age≥65 years, hyperlipidemia and stage IV, hypothyroidism, elevated cysteine C levels, and elevated systemic inflammatory markers such as PLR and SII were further associated with an increased risk of CSVD.
Authors
- Fan Liu
- Na Wu (ORCID: https://orcid.org/0009-0002-5492-3700)
- Dongmei Zhou (ORCID: https://orcid.org/0000-0001-5414-9116)
- Jia Liu (ORCID: https://orcid.org/0000-0001-6046-0664)
- Xiaonan Wang (ORCID: https://orcid.org/0000-0003-3759-778X)
- Xiaoyu Guo (ORCID: https://orcid.org/0000-0003-2622-6676)
- Jiafan Liu (ORCID: https://orcid.org/0000-0002-9720-2471)
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1645549
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Medical University