An impact of type 2 diabetes mellitus on NKT-like cell population in humans: a new insight into impaired immune response in hyperglycemia
Our study demonstrated that DN NKT-like cells, which possess significant cytotoxic activity, are depleted in T2DM patients. These results may explain the novel potential mechanism of increasing susceptibility to infections and cancers in T2DM and emphasize the need for precise glycemic control. The novel insights into NKT-like cell immunomodulation role in T2DM may open new, targeted therapies in metabolic diseases. Further research in larger cohorts is needed to confirm these pioneering observations.
Authors
- Magdalena Stasiak (ORCID: https://orcid.org/0000-0002-2910-7691)
- Bartłomiej Stasiak (ORCID: https://orcid.org/0000-0002-8937-1988)
- Małgorzata Karbownik‐Lewińska (ORCID: https://orcid.org/0000-0002-3045-5669)
- Przemysław Wiktor Śliwka (ORCID: https://orcid.org/0000-0002-2644-8933)
- Andrzej Lewiñski (ORCID: https://orcid.org/0000-0002-8748-3337)
- Emilia Adamska-Fita
Institutions
- Lodz University of Technology (PL)
- Medical University of Lodz (PL)
- Polish Mother’s Memorial Hospital Research Institute (PL)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fendo.2025.1641318
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80