Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes
These findings suggest that lecanemab may help maintain cerebral perfusion and partially preserve gray matter microstructure and white matter integrity during the early course of treatment in patients with MCI, despite concurrent volumetric and microstructural changes. Multimodal MRI may contribute to monitoring treatment response in patients with MCI receiving lecanemab.
Authors
- Ken Niimi
- Tomohiko Asada
- Riki Matsumoto (ORCID: https://orcid.org/0000-0003-3985-9210)
- Ryosuke Takahashi
- Sayaka Ono (ORCID: https://orcid.org/0000-0002-3771-5005)
- Akio Ikeda (ORCID: https://orcid.org/0000-0002-0790-2598)
- Hidenao Fukuyama (ORCID: https://orcid.org/0000-0002-8421-2806)
- Dinh Ha Duy Thuy
- Yasushi Okada
- Kaku Kimura
- T. Takahashi
- Shingo Takenaka
- M. Fukui
Institutions
- Kyoto University (JP)
- Yorkshire Ambulance Service NHS Trust (GB)
- Psychiatric Medical Center (AM)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fnagi.2025.1651596
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00