Anxiety and depression in pediatric patients with disorder of brain-gut interaction: the role of diarrhea and abdominal pain as key determinants

DGBI are strongly associated with elevated rates of anxiety and depression in pediatric populations, with abdominal pain and diarrhea serving as critical symptomatic drivers. Family support emerged as a protective factor against depression. These findings underscore the importance of routine psychological screening and the implementation of integrated, multidisciplinary interventions in the clinical management of DGBI.