Correlation between metformin use and mortality in acute respiratory failure: a retrospective ICU cohort study
Metformin use was significantly associated with decreased short-term mortality among ICU patients with ARF. These findings suggest that metformin, beyond its glucose-lowering effects, may offer survival benefits in critically ill populations. Clinicians should consider the potential role of metformin when managing ICU patients with type 2 diabetes and ARF. Further prospective studies are warranted to confirm these findings and optimize clinical application strategies.
Authors
- Liang Huang (ORCID: https://orcid.org/0000-0002-4789-7068)
- Yuan Wei
- Wei Wei (ORCID: https://orcid.org/0000-0002-0960-7269)
- Jinfeng Liu (ORCID: https://orcid.org/0000-0002-9537-6603)
- Yi Hou (ORCID: https://orcid.org/0000-0003-0447-090X)
- Yunlin Yang
Institutions
- Sichuan University (CN)
- Dar Al-Shifa Hospital (PS)
- West China Second University Hospital of Sichuan University (CN)
- Zhongshan People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fphar.2025.1584230
- Citations
- 1
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Sichuan University