Altered Amyloid-β42 and BACE-1 Proteins in Plasma Astrocyte-Derived Exosomes in Hypertensive Patients With Cerebral Microbleeds
The study revealed that reduced plasma ADE levels of Aβ42 were significantly associated with CMBs in HTN patients. This finding suggests a potential link between HTN-related CMBs and AD-related amyloid-β pathology, offering novel insights into the mechanisms by which HTN-related CMBs promote AD progression.
Authors
- Ran Yao
- Jinbiao Zhang (ORCID: https://orcid.org/0000-0002-6343-1305)
- Bing Leng
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0003-0131-0230)
- Mengfan Li (ORCID: https://orcid.org/0000-0003-1501-9516)
- Hairong Sun
- Tengqun Shen
- Xiaoxiao Liu
- Zhenguang Li
Institutions
- Shandong University (CN)
- Weihai Municipal Hospital (CN)
Publication Details
- Journal
- American Journal of Hypertension
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1093/ajh/hpaf158
- Citations
- 1
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39