A randomized controlled study comparing the intraperitoneal instillation of diluted bupivacaine and non-diluted bupivacaine after laparoscopic cholecystectomy

Background: After a laparoscopic cholecystectomy (LC), postoperative pain is still a major issue even though the procedure is less invasive. Intraperitoneal instillation of local anesthetics such as bupivacaine is commonly used for pain control. However, the impact of dilution on analgesic efficacy remains unclear. Methods: Seventy adult patients receiving elective LC were included in this prospective single-blind randomized controlled research. Patients were randomly allocated to one of two groups: Group A received 20 ml of 0.5% undiluted bupivacaine, and the same dosage was given to Group B, diluted in 480 milliliters of saline. Results: The amount of fentanyl consumed during surgery didn't change considerably in between the two groups. Compared to group A, group B's time to first request rescue analgesia was noticeably delayed (p