Molecular analysis of androgen receptor splice variant AR-V3 reveals eminent ambiguity regarding activity and clinical utility
Our data demonstrate that both AR-V3 isoforms are functionally inactive, lacking autonomous nuclear translocation or transcriptional activity. AR-V3 is not a substrate for NMD, and its protein structure remains poorly defined. While associated with worse overall survival, AR-V3 lacks predictive value for ARTA response, underscoring its limited utility as a biomarker. These findings emphasize the need for functional validation before integrating putative biomarkers into clinical practice.
Authors
- Katrin Schlack (ORCID: https://orcid.org/0000-0001-5843-140X)
- Julia Vieler
- Christof Bernemann (ORCID: https://orcid.org/0000-0001-5415-6367)
- Andres Jan Schrader (ORCID: https://orcid.org/0000-0002-9435-7347)
- Keith A. Seifert (ORCID: https://orcid.org/0000-0001-8877-4796)
- Neele Wüstmann
- Verena Humberg
- Martin Bögemann (ORCID: https://orcid.org/0000-0002-2569-4446)
Institutions
- University Hospital Münster (DE)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12935-025-03948-y
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Deutsche Forschungsgemeinschaft