Anti-CTLA-4 Treatment Abrogates Co-stimulation Blockade-induced Acceptance of Transgenic Porcine Islets in Humanized Mice
The present data demonstrate that long-lasting acceptance of LEA29Y transgenic porcine islet grafts is dependent on CTLA-4/LEA29Y signaling even several months after transplantation. This finding has important implications on safety of pig islet xenotransplantation in patients with type 1 diabetes because it provides a potent tool for graft elimination in case of medical indication.
Authors
- Jochen Seißler (ORCID: https://orcid.org/0000-0002-7404-2364)
- Lelia Wolf‐van Buerck (ORCID: https://orcid.org/0009-0003-8468-6416)
- Eckhard Wolf (ORCID: https://orcid.org/0000-0002-0430-9510)
- Elisabeth Kemter (ORCID: https://orcid.org/0000-0001-7785-7502)
- Nikolai Klymiuk (ORCID: https://orcid.org/0000-0003-3532-1659)
- Constança Figueiredo (ORCID: https://orcid.org/0000-0003-2786-0388)
Institutions
- Medizinische Hochschule Hannover (DE)
- Hôpital Saint-Julien (FR)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Transplantation
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1097/tp.0000000000005512
- Citations
- 1
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 2.01