Stat3-mediated Th17 pathogenicity induced by periodontitis contributes to cognitive impairment by promoting microglial M1 polarization
<i>Stat3</i>-mediated Th17 pathogenicity bridged the correlation between periodontitis and neuroinflammation related to cognitive impairment, offering novel perspectives for a therapeutic target for blocking the mouth-to-brain axis.
Authors
- Hui Shen (ORCID: https://orcid.org/0000-0001-9767-4084)
- Xinyi Xie
- Che Qiu
- Wei Zhou (ORCID: https://orcid.org/0000-0003-3989-4198)
- Zhongchen Song (ORCID: https://orcid.org/0000-0002-9249-7645)
- Yining Zhou
- Huiwen Chen (ORCID: https://orcid.org/0000-0001-9802-2782)
- Lina Xu (ORCID: https://orcid.org/0000-0003-1785-382X)
Institutions
- Shanghai Jiao Tong University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shanghai Stomatological Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Minhang District Central Hospital (CN)
- National Clinical Research (US)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1590665
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- National Key Research and Development Program of China