Application of metagenomics sequencing to diagnose paralytic rabies with stroke-like onset: a case report
Compared to polymerase chain reaction (PCR) and direct fluorescent antibody (DFA) test, mNGS shortens the diagnostic window and improves sensitivity to low-virus or seronegative manifestations by simultaneously capturing and sequencing the entire pathogen genome. The mNGS technology can effectively aid in the diagnosis of paralytic rabies.
Authors
- Xiaozhi Lu (ORCID: https://orcid.org/0000-0002-2517-6331)
- Beth Y. Lin
- Dongyan Zhong
- Shan Deng (ORCID: https://orcid.org/0000-0002-2727-2722)
- Ke Wang (ORCID: https://orcid.org/0000-0002-3406-6708)
- Qianqian Liu (ORCID: https://orcid.org/0000-0003-0661-1139)
- Bo Wang (ORCID: https://orcid.org/0000-0002-6047-1221)
- Qin Lu
- Liya Pan (ORCID: https://orcid.org/0009-0004-2980-8633)
- Liya Wu (ORCID: https://orcid.org/0000-0003-3963-5567)
Institutions
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fmed.2025.1639262
- Primary Topic
- Rabies epidemiology and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Province