Potential protective regulatory effects on radiation−induced esophageal injury in TUT4−/− mice
Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that these DEmRNAs were significantly associated with biological processes including lipid metabolism, fatty acid metabolism, proteolysis, and broader metabolic functions. Notably, DEmRNAs in TUT4<sup>-/-</sup> esophageal tissues showed marked enrichment in the renin-angiotensin system and peroxisome proliferator-activated receptor signaling pathways, implicating their potential roles in the pathogenesis of radiation-induced esophageal injury. In addition, we identified a regulatory axis in which a long non-coding RNA competes with miR-182 to modulate the competing endogenous RNA network governing TUT4 target genes. Collectively, our transcriptomic analysis offers novel mechanistic insights into how TUT4 may confer protection against radiation-induced damage in esophageal tissues.
Authors
- Zhiqiang Sun (ORCID: https://orcid.org/0000-0003-1977-5263)
- Renhua Huang
- Judong Luo
- Bo Gao
- Huiwen Ren (ORCID: https://orcid.org/0000-0002-6037-8561)
- Wei Li (ORCID: https://orcid.org/0000-0002-6329-198X)
- Zhigang Fan (ORCID: https://orcid.org/0000-0002-1190-0894)
- Jianlin Wang (ORCID: https://orcid.org/0000-0002-9528-6798)
Institutions
- Tongji University (CN)
- Renji Hospital (CN)
- Soochow University (CN)
- Shanghai Tenth People's Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Changzhou Third People's Hospital (CN)
- Tongji Hospital (CN)
- Fourth People's Hospital of Changzhou (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fonc.2025.1600597
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tongji University