Prediction and effect on relapse of natural killer cell alloreactivity based on KIR-HLA interactions in pediatric haploidentical transplantation with anti-thymoglobulin
These results indicate that pediatric patients exhibiting NK cell alloreactivity, as predicted by the KIR3DL2-A3/A11 combination, had a significantly lower cumulative incidence of relapse. Furthermore, alloreactivity predicted by Synthesis-iKIR was significantly associated with improved overall survival. These findings have not been previously validated in pediatric studies and may have clinical relevance for haploidentical transplantation population, pending confirmation in larger cohorts.
Authors
- Xiangfeng Tang (ORCID: https://orcid.org/0000-0002-0672-6983)
- Maoquan Qin (ORCID: https://orcid.org/0000-0003-2704-8592)
- Wei Cao (ORCID: https://orcid.org/0000-0001-6133-1020)
- Yingjian Si
- Yanhui Luo (ORCID: https://orcid.org/0000-0001-8714-5883)
- Wei Chen (ORCID: https://orcid.org/0000-0003-2275-4527)
- Xiangjun Liu (ORCID: https://orcid.org/0000-0001-5177-4995)
- Wei Lu (ORCID: https://orcid.org/0000-0003-2383-7084)
- Guosheng Xing
- Hai-Fei Zhou
Institutions
- Chinese PLA General Hospital (CN)
- Annoroad Gene Technology (China) (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1643244
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00