MicroRNA-132 regulates quinolinic acid production in the brain during LPS-induced neuroinflammation
Collectively, these findings suggest that the miR-132/212 cluster functions as a novel modulator of KP metabolism during LPS-induced inflammation, and acts as a potential therapeutic target for controlling neurotoxic QUIN accumulation in neuroinflammatory conditions.
Authors
- Delphine Allorge (ORCID: https://orcid.org/0000-0003-2356-3319)
- Sabrina Marion (ORCID: https://orcid.org/0000-0001-7824-955X)
- Benjamin Hennart (ORCID: https://orcid.org/0000-0003-0302-6049)
- Sébastien S. Hébert (ORCID: https://orcid.org/0000-0002-0391-9325)
- Papa Yaya Badiane
- Amir Mohamed Kezai
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre hospitalier universitaire de Québec (CA)
- Center for Infection and Immunity of Lille (FR)
- Université Laval (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1644783
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé