CPAP modulation of sleep microstructure (N2-SSD and REM-AHI) as predictors of neurological recovery in ischemic stroke patients with moderate-to-severe OSA
CPAP therapy enhances sleep microstructure and oxygenation parameters, which improves sleep quality. N2-SSD, REM-AHI, and Mean SpO<sub>2</sub> are mechanistically linked to functional prognosis and CPAP exerts therapeutic effects through the modulation of these biomarkers. Early CPAP intervention targeting REM-AHI and N2-SSD demonstrates prognostic benefits, which suggests that sleep microstructure-specific metrics may serve as precision therapeutic targets.
Authors
- Gang Xu (ORCID: https://orcid.org/0000-0002-8991-3660)
- Tieyu Tang (ORCID: https://orcid.org/0000-0002-6365-2335)
- Wenyi Yu (ORCID: https://orcid.org/0000-0003-3455-3087)
- Tianyu Jing (ORCID: https://orcid.org/0000-0002-8439-8778)
- Yixi Zheng
- C.‐C. Chu (ORCID: https://orcid.org/0000-0002-6008-0466)
- Shutong Sun
- Xingmin Shen
- Liwen Xu
Institutions
- Jiangyin People's Hospital (CN)
- Wuxi Third People's Hospital (CN)
- People's Hospital of Yangzhong (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fneur.2025.1605106
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Yangzhou City
- Yangzhou University