Evaluating functional C1INH with multiple laboratory methods across Hereditary Angioedema types
DBS-based LC-MS/MS and ELISA-FXIIa offer promising accuracy and broader applicability for early diagnosis of HAE types 1 and 2. The use of novel substrates and the inclusion of a clinically realistic cohort may enhance the translational relevance of these findings.
Authors
- Rosemeire Navickas Constantino-Silva
- Anete Sevciovic Grumach (ORCID: https://orcid.org/0000-0002-9803-0309)
- Solange Oliveira Rodrigues Valle (ORCID: https://orcid.org/0000-0001-5512-7349)
- João Bosco Pesquero (ORCID: https://orcid.org/0000-0002-4507-632X)
- Pedro Francisco Giavina-Bianchi Junior (ORCID: https://orcid.org/0000-0002-1034-7580)
- Maine Luellah Demaret Bardou (ORCID: https://orcid.org/0000-0001-9831-4080)
- Ana Júlia Ribeiro Teixeira
- Eli Mansour (ORCID: https://orcid.org/0000-0001-6450-6930)
- Maria Luiza Oliva Alonso (ORCID: https://orcid.org/0000-0001-7879-7134)
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Hospital Universitário Clementino Fraga Filho (BR)
- Faculdade de Medicina do ABC (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1654078
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Shire
- Faculdade de Medicina do ABC
- Takeda Pharmaceuticals International