Residual/recurrent lesions after cold-knife conization for high-grade cervical intraepithelial neoplasia: risk factor analysis and clinical management recommendations

Risk factors associated with RLC and RLH must be considered when implementing targeted clinical interventions. Elongating the clinical follow-up period is of paramount importance, particularly for patients with high-risk factors; therefore, it is recommended that follow-up intervals be reduced. For patients with HPV16/18 infection, positive margins, and positive ECC, it is recommended that a hysterectomy be performed whenever necessary.