Two-part model for ventilator-free days in a cluster randomized cross-over clinical trial
The proposed two-part model provides a more comprehensive assessment of intervention effects on ventilator-free days in critical care trials. Researchers and clinicians can obtain greater insights with this approach about the direction and magnitude of the intervention effects on mortality, ROSC, and duration of mechanical ventilation.
Authors
- Henry E. Wang (ORCID: https://orcid.org/0000-0002-4738-0093)
- Ari Moskowitz (ORCID: https://orcid.org/0009-0003-5223-3121)
- Michelle N. Gong (ORCID: https://orcid.org/0000-0001-7952-5384)
- Yungtai Lo (ORCID: https://orcid.org/0000-0002-2694-4830)
- Mimi Kim (ORCID: https://orcid.org/0000-0001-9651-7124)
- Xianhong Xie (ORCID: https://orcid.org/0000-0002-2032-1587)
Institutions
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- The Ohio State University (US)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12874-025-02653-8
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences