Candidemia in the Dominican Republic: species distribution, resistance, clinical characteristics, and outcomes at a tertiary care hospital

Bloodstream infections (BSIs) caused by <i>Candida</i> are a significant cause of morbidity and mortality. Geographical variations exist in the epidemiology of candidemia, with a paucity of data in the many low- and middle-income countries. We performed a retrospective study of candidemia from 2017 to 2022 at a 289-bed teaching hospital in the Dominican Republic (DR). A total of 197 cases were reviewed. Overall mortality rate was 49.2%. Age and vasopressor use were associated with mortality. The most prevalent <i>Candida</i> species were <i>C. tropicalis</i> and <i>C. parapsilosis. C. albicans</i> was 12% resistance to amphotericin B. These findings underscore the importance of understanding local epidemiology and may help inform empiric therapy and the development of treatment guidelines in the DR.