Meta-Analysis of the Effect of Nutritional Support on Treatment Tolerance and Complications during Chemotherapy for Bone Tumors

Objective: To evaluate the effects of nutritional support on treatment tolerance and complications in patients with bone tumors undergoing chemotherapy via a meta-analysis. Methods: The China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, and Web of Science databases were searched from inception to February 2025 for clinical controlled trials on nutritional support for patients with bone tumors during chemotherapy. Review Manager 5.3 software was used to conduct a meta-analysis of the included studies. Results: A total of 11 studies involving 935 patients were included. The meta-analysis indicated that nutritional support significantly improved hemoglobin (MD = 5.70, 95% CI: 4.30 - 7.10, P P P = 0.04). It also reduced the incidence of complications (OR = 0.33, 95% CI: 0.20 - 0.55, P P = 0.0007), shortened the length of hospital stay (MD = −0.72, 95% CI: −1.10 - −0.34, P = 0.0002), alleviated negative emotions (MD = 11.60, 95% CI: 10.16 - 13.04, P P P Conclusion: Nutritional support can significantly improve treatment tolerance and reduce the risk of complications in patients with bone tumors undergoing chemotherapy. However, these findings require further validation through additional high-quality studies.