Irregular Terpenoids From the Medicinal Herb <i>Gentianella pygmaea</i>
Three new irregular terpenoids, gentianellins A-C (1-3), along with two known analogues (4 and 5), were isolated from the whole plants of the medicinal herb Gentianella pygmaea. Their structures were elucidated by extensive spectroscopic analysis (1D and 2D NMR and HRMS) and quantum chemical calculations. Moderate anti-inflammatory activity of the new isolates was observed via suppressing the secretion of cytokines TNF-α and IL-6 in LPS-induced macrophages RAW264.7, with IC<sub>50</sub> values ranging from 13.30 to 25.41 µM, respectively.
Authors
- An‐Yu Li
- You Xu (ORCID: https://orcid.org/0000-0001-9024-281X)
- Xue‐Fei Li
- Kai Guo
- Y. Z. Fan (ORCID: https://orcid.org/0000-0002-9039-719X)
- Sheng‐Hong Li (ORCID: https://orcid.org/0000-0001-5404-893X)
- Jingyi Tang (ORCID: https://orcid.org/0000-0001-5560-1223)
- Yan Liu (ORCID: https://orcid.org/0000-0002-8195-3772)
- Xiao‐Yu Qi
Institutions
- Kunming Institute of Botany (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1002/cbdv.202502320
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00