Integrated single-cell and bulk RNA-sequencing data reveal prognosis and therapeutic response in low-grade glioma based on hypoxia-lactylation related genes
The constructed 4-gene hypoxia-lactylation prognostic model can effectively predict survival risk in LGG patients. The high-risk group is characterized by activation of pro-tumorigenic pathways, high immune infiltration, and sensitivity to specific targeted drugs. FABP5 + TAMs participate in LGG progression by regulating lipid metabolism and inflammatory responses, representing a potential therapeutic target.
Authors
- Hongyu Tang (ORCID: https://orcid.org/0009-0003-7663-099X)
- Ying Xin Xu (ORCID: https://orcid.org/0000-0001-9570-8666)
- Lianping Gu
- Xu Wang (ORCID: https://orcid.org/0000-0003-4254-9416)
- Yaohua Liu (ORCID: https://orcid.org/0000-0002-5867-5065)
- Ruijie Zhang (ORCID: https://orcid.org/0000-0001-7894-8705)
- Jingyan Gu (ORCID: https://orcid.org/0009-0008-2968-2048)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- SAIC-GM (China) (CN)
- Shanghai First People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1007/s12672-025-03459-2
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China