A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection

Viruses are versatile colloidal materials in their biofunctions, monodispersed and periodic structures, and high surface designability. For expanding the applicability of virus-based materials, spatiotemporally controlled immobilization and dispersion of viruses with retained activity should be useful, though control of the dynamic nature of viruses hybridized with commonly used polymers has been difficult due to their strong interactions. Here, we report a self-assembling peptide (A2Az) enabling photo control of adhesion and dispersion of M13 bacteriophage virus (M13 phage) and successfully demonstrate patterning of localization and infection of the virus. A2Az is a cationic peptide with amphiphilicity that consists of eight amino acid residues containing a photo-responsive azobenzene group at the second position and self-assembles into a helical supramolecular fiber to form a hydrogel. The helical fibrillar morphology of A2Az exhibits strong interaction with M13 phage, allowing for immobilization not only on a two-dimensional surface but also in a three-dimensional hydrogel with suppression of infectivity. The A2Az fiber undergoes a light-triggered fiber-to-particle transition and releases the immobilized M13 phage with retained infectivity for the photo-controlled patterning of localization and infection. This approach has potential applicability to various virus-based biomaterials, such as structural materials and materials for photo-selective gene transfection to cells.

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Publication Details

Journal
Angewandte Chemie International Edition
Published
2025-08-25
DOI
https://doi.org/10.1002/anie.202508528
Primary Topic
Bacteriophages and microbial interactions
Type
article
Field-Weighted Citation Impact
0.00

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article

A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection

Teruhiko Matsubara, Atsuya Yaguchi, Itsuki Ajioka, Toshinori Sato et al.
Angewandte Chemie International Edition
Bacteriophages and microbial interactions
article

A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection

Teruhiko Matsubara, Atsuya Yaguchi, Itsuki Ajioka, Toshinori Sato, Daiki Miura, Takahiro Muraoka, Noriyuki Uchida, Hirotsugu Hiramatsu, Go Watanabe, Takeshi Saito, Shunto Itani, Chinbat Enkhzaya
article en

Abstract

Viruses are versatile colloidal materials in their biofunctions, monodispersed and periodic structures, and high surface designability. For expanding the applicability of virus-based materials, spatiotemporally controlled immobilization and dispersion of viruses with retained activity should be useful, though control of the dynamic nature of viruses hybridized with commonly used polymers has been difficult due to their strong interactions. Here, we report a self-assembling peptide (A2Az) enabling photo control of adhesion and dispersion of M13 bacteriophage virus (M13 phage) and successfully demonstrate patterning of localization and infection of the virus. A2Az is a cationic peptide with amphiphilicity that consists of eight amino acid residues containing a photo-responsive azobenzene group at the second position and self-assembles into a helical supramolecular fiber to form a hydrogel. The helical fibrillar morphology of A2Az exhibits strong interaction with M13 phage, allowing for immobilization not only on a two-dimensional surface but also in a three-dimensional hydrogel with suppression of infectivity. The A2Az fiber undergoes a light-triggered fiber-to-particle transition and releases the immobilized M13 phage with retained infectivity for the photo-controlled patterning of localization and infection. This approach has potential applicability to various virus-based biomaterials, such as structural materials and materials for photo-selective gene transfection to cells.

Angewandte Chemie International EditionVol. 64(41)
Tokyo Institute of Technology (JP), Tokyo Medical and Dental University (JP), National Yang Ming Chiao Tung University (TW), Keio University (JP), Kanagawa Academy of Science and Technology (JP), Kitasato University (JP), The University of Tokyo (JP), Tokyo University of Agriculture and Technology (JP)
Canon Foundation in Europe, Asahi Glass Foundation, Japan Association for Chemical Innovation, Urakami Foundation for Food and Food Culture Promotion, Ministry of Education, Culture, Sports, Science and Technology, New Energy and Industrial Technology Development Organization, Tokyo University of Agriculture, Soochow University, Tokyo University of Agriculture and Technology, Toyota Physical and Chemical Research Institute, Lotte Foundation, Japan Society for the Promotion of Science, Core Research for Evolutional Science and Technology, ACT-X
Openalex Percentile: Top 78%
Bacteriophages and microbial interactions
DOIOpen Access PDFOpenAlex
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