Sophora moocroftiana seeds ethanol extract regulates NLRP3 inflammasome activation and pyroptosis via ROS/TXNIP pathway to amelioration of NAFLD in vitro and in vivo
SMS has promising therapeutic potential in NAFLD management by inhibiting the activation of the NLRP3 inflammasome and pyroptosis via ROS/TXNIP pathway in hepatocytes.
Authors
- Ruiying Yuan (ORCID: https://orcid.org/0000-0001-8513-5892)
- Shan Huang (ORCID: https://orcid.org/0000-0002-4436-3327)
- Zhuoma Dongzhi (ORCID: https://orcid.org/0000-0001-7486-7908)
- Ming Gui (ORCID: https://orcid.org/0000-0002-4944-808X)
- Sicen Wang (ORCID: https://orcid.org/0000-0002-2757-3277)
- Bin Li (ORCID: https://orcid.org/0000-0001-6079-1076)
- Ge Yang (ORCID: https://orcid.org/0000-0003-0918-7329)
- Wendong Zhang (ORCID: https://orcid.org/0000-0003-1762-9246)
- Yangzhen Ciren
Institutions
- Qingdao University of Science and Technology (CN)
- Xiamen University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fphar.2025.1622178
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China