Restarting Oral Anticoagulation in Patients With Atrial Fibrillation After Admission for a Gastrointestinal Bleeding Event: Effectiveness and Safety of Direct Oral Anticoagulants Compared to Warfarin
Among patients with AF who survived and resumed oral anticoagulation within the first 90 days after hospitalization for a major GIB event, restarting oral anticoagulation treatment with DOACs was associated with a lower risk of subsequent hospitalization for major bleeding and the composite outcome of ischemic stroke, SE, all-cause mortality, and recurrent or incident major bleeding.
Authors
- Oluwadolapo D. Lawal (ORCID: https://orcid.org/0000-0003-4466-6675)
- Fisayomi Shobayo
- Tracey H. Taveira (ORCID: https://orcid.org/0000-0003-0625-6851)
- Kelly L. Matson (ORCID: https://orcid.org/0000-0001-7960-690X)
- Herbert D. Aronow (ORCID: https://orcid.org/0000-0002-9061-7893)
- Xuerong Wen (ORCID: https://orcid.org/0000-0002-4803-7895)
- Justin Gold (ORCID: https://orcid.org/0000-0003-0497-9976)
- Yichi Zhang (ORCID: https://orcid.org/0000-0002-2280-7599)
- Anne L. Hume
Institutions
- University of Rhode Island (US)
- Providence College (US)
- Brown University (US)
- Providence VA Medical Center (US)
- Cooper Medical School of Rowan University (US)
- Lifespan (US)
- The University of Texas Health Science Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1002/phar.70055
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00