Effects of gut microbiota on cognitive impairment in Parkinson’s disease: a comprehensive Mendelian randomization and case–control study
Our study confirms the potential role of <i>Subdoligranulum</i> in PDD progression, potentially mediated through starch and sucrose metabolism. These findings highlight the importance of the gut-brain axis in PDD and may provide insights into targeted interventions for PDD.
Authors
- Hao Zhou (ORCID: https://orcid.org/0000-0001-5648-0574)
- Qi Chang (ORCID: https://orcid.org/0000-0001-9546-1827)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-8320-7263)
- Tao Chen (ORCID: https://orcid.org/0000-0003-3401-725X)
- Weiguo Liu (ORCID: https://orcid.org/0000-0001-5916-9837)
- Ling Xie (ORCID: https://orcid.org/0000-0003-2943-3080)
- Yukun Feng (ORCID: https://orcid.org/0009-0002-5467-5954)
- Xueyang Deng
Institutions
- China Pharmaceutical University (CN)
- Nanjing Brain Hospital (CN)
- Hainan Center for Disease Control & Prevention (CN)
- Hainan General Hospital (CN)
- Nanjing Jiangning Hospital (CN)
- State Key Laboratory of Natural Medicine
- Hainan Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fmicb.2025.1620449
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province