Quercetin promotes angiogenesis and protects the blood-spinal cord barrier structure after spinal cord injury by targeting the PI3K/Akt signaling pathway
These findings suggest that QCT can promote the regeneration of blood vessels in the injured spinal cord and protect the structure of the BSCB by activating the PI3K/Akt signaling pathway, thereby enhancing the neurological function of rats following SCI.
Authors
- Dawei Sun (ORCID: https://orcid.org/0000-0003-1551-4349)
- Yeyang Wang (ORCID: https://orcid.org/0000-0001-7736-1961)
- Lei Yang (ORCID: https://orcid.org/0000-0003-1461-8111)
- Xinfang Liu (ORCID: https://orcid.org/0000-0003-2259-9109)
- Xuhua Liu (ORCID: https://orcid.org/0000-0002-6919-8292)
- Keqiang Li (ORCID: https://orcid.org/0000-0002-9482-147X)
- Chang Chen (ORCID: https://orcid.org/0000-0003-1674-973X)
- Sheng Luo
- Jinbo Lin
- Lina Wei (ORCID: https://orcid.org/0000-0001-5427-7169)
- Man Xiong (ORCID: https://orcid.org/0000-0003-4948-9495)
- Sidong Luo
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- Guangdong Medical College (CN)
- Zhaoqing University (CN)
- Guangdong Pharmaceutical University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- The First People's Hospital of Zhaoqing (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s12967-025-06973-7
- Citations
- 4
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Department of Education of Guangdong Province
- Guangzhou University of Chinese Medicine
- Traditional Chinese Medicine Bureau of Guangdong Province
- Guangzhou University
- Medical Science and Technology Foundation of Guangdong Province
- Guangzhou Municipal Science and Technology Project