Assessment of ocular coherence tomography angiography changes in center and non-center involved diabetic macular edema

Background: Diabetes mellitus (DM) is one of the world’s fastest-growing chronic illnesses. Purpose: To assess changes in center and non-center involved diabetic macular edema utilizing ocular coherence tomography angiography. Patients and Methods: This research was done on 21 diabetic cases (38 eyes), 15 females and 6 males with average age (57 ±9) years old and mean duration of diabetes is 10 years. Cases with center involved DME are 27 cases while cases with non-center involved DME are 11 cases. Cases include 20 eyes with mild NPDR, six eyes with moderate NPDR, 7 eyes with severe NPDR, and 5 eyes with PDR. The normality of distribution for the examined factors have been examined utilizing Shapiro test assuming normality at P-value above 0.05. Informed written consent has been obtained from all the cases that fulfilled the inclusion-exclusion criteria, followed by detailed ophthalmological investigation has been performed. Patients underwent OCTA exam and the results are studied using The Pearson correlation coefficient. Results: SVD was statistically significant higher in non-center involved DME (p-value below 0.05). There is greatly significant positive association between superficial and deep vessel density. There is no statistically significant relationship between type of diabetic macular edema with Age, sex, duration of D.M. or FAZ. Conclusion: SVD is higher in non-center involved DME than in center involved DME, while there is no statistical relation between type of DME and age, sex, duration of D.M. or FAZ.