Impact of CYP3A4 and CYP3A5 polymorphisms on tacrolimus dose requirements in Saudi kidney transplant patients
This study highlights the high prevalence of the CYP3A5*3/*3 genotype and wild-type CYP3A4 alleles in the Saudi population. The genetic variability significantly affects Tac trough levels and dosing requirements necessary to achieve therapeutic targets. These findings underscore the importance of pharmacogeneticguided Tac dosing to optimize therapeutic outcomes in SKTP.
Authors
- Mai A. Alim A. Sattar Ahmad
- Hadiah Bassam Al Mahdi (ORCID: https://orcid.org/0000-0003-3483-9499)
- Zoheir A. Damanhouri (ORCID: https://orcid.org/0000-0002-9150-5471)
- Mohammad F. Zaitoun
- Ahmed S. Ali (ORCID: https://orcid.org/0000-0002-3341-8177)
- Ezz H Abdelfattah
- Sherif Edris (ORCID: https://orcid.org/0000-0002-2810-3736)
- Feras Alharbi (ORCID: https://orcid.org/0000-0003-3275-2250)
- Marzog S Al Nasser
Institutions
- King Abdulaziz University (SA)
- Armed Forces Hospital (SA)
Publication Details
- Journal
- Saudi Pharmaceutical Journal
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1007/s44446-025-00035-1
- Citations
- 2
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.97