Pneumonia, meningitis, and endocarditis caused by Staphylococcus aureus in a patient living with HIV/AIDS

Invasive Staphylococcus aureus infections, in particular those caused by methicillin-resistant strains (MRSA), are a major clinical challenge, especially in immunocompromised individuals. Patients living with HIV/AIDS are at increased risk of MRSA colonization and infection with potentially severe and multisystemic clinical presentations. This report describes the case of a 43-year-old man who initially presented with skin lesions and then developed severe systemic pneumonia, meningitis, and infective endocarditis caused by MRSA. The patient was treated with prolonged antibiotic therapy and had a favorable outcome after 2 months of hospitalization.