Pillarureaarenes: Urea-Embedded Pillararenes for Amino Acid Derivative Recognition
A three-dimensional pillarureaarene (<b>P3U6A</b>) was synthesized via fragment-coupling cyclization of dialkoxybenzene and urea units. Single-crystal analysis revealed a shield-shaped structure stabilized by intramolecular hydrogen bonds. The macrocycle demonstrated strong binding with phenylalanine ethyl ester salts. Further derivatization gave <b>P3EU6A</b>, showing chiral recognition of a series of amino acid derivatives via induced circular dichroism (CD). This work introduces a versatile platform for constructing urea-embedded pillararenes with potential applications in host-guest chemistry and chirality sensing.
Authors
- Wenhao Lin (ORCID: https://orcid.org/0000-0002-8689-7968)
- Shengke Li (ORCID: https://orcid.org/0000-0003-4608-0117)
- Kai Diao (ORCID: https://orcid.org/0000-0002-1332-5133)
- Robert B. P. Elmes (ORCID: https://orcid.org/0000-0001-7898-903X)
- Qing Liu (ORCID: https://orcid.org/0000-0002-8473-6511)
- Tangxin Xiao (ORCID: https://orcid.org/0000-0002-2864-9587)
- Wang Xie (ORCID: https://orcid.org/0009-0003-6627-9702)
- Mingyue Wen (ORCID: https://orcid.org/0000-0002-2767-4027)
- Leyong Wang (ORCID: https://orcid.org/0000-0001-5775-3714)
Institutions
- Xihua University (CN)
- Target (United States) (US)
- National University of Ireland, Maynooth (IE)
- Nantong University (CN)
- Catalytic Materials (United States) (US)
- Changzhou University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1021/acs.orglett.5c03042
- Citations
- 8
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China