MAFLD outperforms NAFLD in identifying metabolic dysfunction in U.S. adolescents: a NHANES 2017–2020 analysis
This study demonstrates that while MAFLD and NAFLD share obesity as a core risk factor, MAFLD more specifically identifies adolescents with severe metabolic dysfunction and provides superior risk stratification. The stronger metabolic dysfunction associations and greater model complexity support MAFLD's clinical utility for early intervention in high-risk youth populations.
Authors
- Hu Chen (ORCID: https://orcid.org/0000-0003-3297-2747)
- Qinghua Yang (ORCID: https://orcid.org/0000-0001-7390-0665)
- Zhaomeng Zhuang (ORCID: https://orcid.org/0000-0002-5328-2465)
- Yigui Zou
- Wenwen Li (ORCID: https://orcid.org/0000-0002-9036-4179)
- Ziyuan Li (ORCID: https://orcid.org/0000-0002-6759-0717)
- Yu Dai (ORCID: https://orcid.org/0000-0001-7929-2760)
- Dongling Dai (ORCID: https://orcid.org/0000-0003-4808-3418)
- Betty P.C. Lin
Institutions
- Southern University of Science and Technology (CN)
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s12876-025-04170-w
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shenzhen Science and Technology Innovation Program