THE EFFECTIVENESS OF ANTIBACTERIAL DRUGS IN PATIENTS OF THE PSKOV REGIONAL CLINICAL HOSPITAL

Introduction. The problem of bacterial resistance to antimicrobials is causing more and more damage to healthcare every year. Antibiotics are used by patients and doctors everywhere, not always justifiably and often in the wrong combinations, which only enhances the adaptation and mutation of infectious disease pathogens. Another important fact is the lack of new antibacterial agents on the market. The aim of the study was to analyze the effectiveness of the use of antibacterial drugs by patients of the Pskov Regional Infectious Diseases Clinical Hospital. Methods. The study is based on the use of microscopic and bacterioscopic methods. The determination of antibiotic resistance was carried out using a disco-diffusion method of investigation on a VITEK 2 Compact analyzer (BioMerieux, France) using VITEK 2 GN and AST-XN-05 diagnostic cards in accordance with the manufacturer's instructions. Results and discussions. The study found that the most detectable and most antibiotic-resistant types of microorganisms belong to the group of particularly dangerous ESKAPE pathogens proposed by WHO. This indicates the absence of any specific endemic pathogens’ characteristic of patients of the Pskov Regional Infectious Clinical Hospital. The least effective drugs in the study were penicillin antibiotics (Ampicillin, Benzylpenicillin, Amoxicillin) and cephalosporin antibiotics (Cefepime, Ceftazidime). This is due to the formation of perfect mechanisms of resistance to these drugs in microorganisms. The most effective drug of the Tetracycline series is Tigecycline. However, the drug is classified by WHO as an antibacterial agent of the last reserve. The implementation of this antibiotic should be carried out under strict control, in order to prevent the development of perfect mechanisms of resistance to this drug in microorganisms.