Synthesis of Triaryl‐Substituted Acyclic Olefins via Palladium‐Catalyzed γ‐C(sp ³ )‐H Diarylation of 2‐(2‐Phenylpropyl)pyridine Derivatives

Abstract This study presents an efficient method for synthesizing triaryl‐substituted acyclic olefins, employing palladium‐catalyzed diarylation of primary C(sp 3 )─H bonds at the γ‐position of 2‐(2‐phenylpropyl)pyridine derivatives, using halogen‐substituted aryl boronic esters as coupling reagents. Intramolecular β‐hydride elimination plays a key role in facilitating the formation of these compounds. The diarylation reaction proceeds smoothly with high functional group tolerance and good yields, even on a gram scale. Preliminary mechanistic studies suggest that the reaction may proceed through a Pd(II)/Pd(IV) catalytic cycle. This approach offers a novel strategy for the one‐pot synthesis of triaryl‐substituted acyclic olefin derivatives.