Synthesis and Enantioselective Recognition of Chiral Macrocycles with Abundant Binding Sites
Chiral macrocycles <i>R</i>/<i>S</i>-C with abundant recognition sites were synthesized via a simple four-step reaction procedure. These homochiral macrocycles can be easily purified by silica gel column chromatography without the demand for chiral separation. Their structures have been carefully characterized using X-ray crystallography and NMR spectroscopy. <i>R</i>/<i>S</i>-C exhibits enantioselective recognition toward a class of chiral drug intermediates, with an enantioselectivity reaching up to 9.6.
Authors
- Dong Tian (ORCID: https://orcid.org/0000-0001-8510-8309)
- Hui Min (ORCID: https://orcid.org/0000-0001-6415-3557)
- Chunju Li (ORCID: https://orcid.org/0000-0001-7450-4867)
- Rui Tan
- Kai Zheng (ORCID: https://orcid.org/0000-0001-9275-1239)
- Chenchen Shen
- Wenting Wu (ORCID: https://orcid.org/0000-0003-0982-771X)
- Jingjing Li (ORCID: https://orcid.org/0000-0002-2088-868X)
- Yi Zhang (ORCID: https://orcid.org/0000-0003-0309-8675)
- Zhiyuan Zhang (ORCID: https://orcid.org/0000-0001-9683-5034)
- Xue Zhang (ORCID: https://orcid.org/0000-0001-7995-9879)
- Ming Dong (ORCID: https://orcid.org/0000-0002-9121-6020)
- Yaohua Liu
- Anqi Hu (ORCID: https://orcid.org/0000-0001-7162-7693)
- Yueyi Zhang (ORCID: https://orcid.org/0000-0003-0788-8826)
Institutions
- Tianjin University of Commerce (CN)
- Tianjin University of Science and Technology (CN)
- Tianjin Normal University (CN)
- National University of Defense Technology (CN)
- CAS Key Laboratory of Urban Pollutant Conversion (CN)
- Center for Interdisciplinary Studies (IN)
- Hubei Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1021/acs.orglett.5c03307
- Citations
- 1
- Primary Topic
- Analytical Chemistry and Chromatography
- Type
- article
- Field-Weighted Citation Impact
- 0.76
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City