Synthesis of Poly‐Substituted Imidazo[1,2‐ <i>a</i> ]Pyridines via a Double Annulation Strategy

Abstract A highly efficient domino process consisting of conjugate substitution, nucleophilic addition, and cycloisomerization from the reaction of enaminonitrile with propargylamine allowed for a successive double ring closure to afford a densely functionalized imidazo[1,2‐ a ]pyridine through formation of three C─N bonds.