Leptin enhances the efficacy of glucantime to modulate macrophage polarization toward the M1 phenotype in Leishmania tropica-infected macrophages
The findings indicate that leptin enhances the efficacy of glucantime against L. tropica by promoting M1 macrophage polarization. This presents a potential therapeutic approach that may lower conventional drug doses and associated toxicity while preserving or even improving treatment outcomes.
Authors
- Iraj Sharifi (ORCID: https://orcid.org/0000-0002-6894-6834)
- Ehsan Salarkia (ORCID: https://orcid.org/0000-0001-6125-5101)
- Abdollah Jafarzadeh (ORCID: https://orcid.org/0000-0002-8180-0602)
- Alireza Keyhani (ORCID: https://orcid.org/0000-0002-1171-387X)
Institutions
- Kerman University of Medical Sciences (IR)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s13071-025-07004-6
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kerman University of Medical Sciences
- Vice Chancellor for Research and Technology, Kerman University of Medical Sciences