Divergent roles of endothelial and red blood cell nitric oxide synthase in regulating cardiovascular function during anemia
Anemia mitigates the BP elevation caused by RBC-eNOS deletion, while hypertension persists in the absence of endothelial eNOS, highlighting vascular eNOS as the predominant regulator of BP under anemic conditions. RBC-eNOS limits infarct size under anemic conditions.
Authors
- Stefanie Becher
- Norbert Gerdes (ORCID: https://orcid.org/0000-0002-4546-7208)
- Malte Kelm (ORCID: https://orcid.org/0000-0003-0060-1052)
- Christian Jung (ORCID: https://orcid.org/0000-0001-8325-250X)
- Lilly Jäger
- Ramesh Chennupati (ORCID: https://orcid.org/0000-0002-3994-5285)
- Miriam M. Cortese‐Krott (ORCID: https://orcid.org/0000-0002-0593-1192)
- Isabella Solga
- Patricia Wischmann (ORCID: https://orcid.org/0000-0002-7442-6915)
- Vithya Yogathasan
Institutions
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Nitric Oxide
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.niox.2025.08.004
- Citations
- 1
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.16