Proliferative Cell Targeting and Epithelial Cell Turnover Fuels Hepatitis E Virus Replication in Human Intestinal Enteroids
Overall, we established a robust HEV-HIE model that yields high titers of infectious nonenveloped virions. Proliferative cells and the fast intestinal epithelial cell turnover are important features that facilitate efficient HEV replication, and likely also its dissemination. This study suggests that the gut is an HEV reservoir, capable of producing some of the nonenveloped HEV shed in the feces.
Authors
- Laura Corneillie (ORCID: https://orcid.org/0000-0003-3937-7000)
- Joana Rocha‐Pereira (ORCID: https://orcid.org/0000-0001-8299-3787)
- Suzanne J. F. Kaptein (ORCID: https://orcid.org/0000-0002-7935-0219)
- Laurence Cocquerel (ORCID: https://orcid.org/0000-0002-2136-5178)
- Winston Chiu (ORCID: https://orcid.org/0000-0001-5236-623X)
- Nânci Santos-Ferreira (ORCID: https://orcid.org/0000-0003-4995-5580)
- Jana Van Dycke (ORCID: https://orcid.org/0000-0003-1632-3499)
- Johan Neyts (ORCID: https://orcid.org/0000-0002-0033-7514)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-1119-9399)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Rega Institute for Medical Research (BE)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Center for Infection and Immunity of Lille (FR)
- KU Leuven (BE)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.gastha.2025.100769
- Citations
- 3
- Primary Topic
- Hepatitis Viruses Studies and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- China Scholarship Council
- Rega Foundation
- National Institutes of Health
- Medical School, University of Michigan
- National Institute of Allergy and Infectious Diseases