Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Our study reveals a critical role for chronic GC-GR signaling in modulating HSC function, promoting myeloid output, and impairing B-cell development. The P2H1<sup>Ad.Cortex</sup> mouse model provides a valuable system to study the hematopoietic consequences of prolonged endogenous glucocorticoid exposure and may aid in understanding the hematologic complications of chronic GC therapy.
Authors
- Anupam Sinha (ORCID: https://orcid.org/0000-0002-2318-3511)
- Ben Wielockx (ORCID: https://orcid.org/0000-0002-4923-2596)
- Ulrike Baschant (ORCID: https://orcid.org/0000-0002-6862-1650)
- Mangesh T. Jaykar
- Triantafyllos Chavakis
- Martina Rauner (ORCID: https://orcid.org/0000-0002-4067-6799)
- Ali El‐Armouche
- Deepika Watts (ORCID: https://orcid.org/0000-0002-7542-2545)
- Peter Mirtschink (ORCID: https://orcid.org/0000-0001-5832-1673)
- Tatyana Grinenko (ORCID: https://orcid.org/0000-0002-2582-1417)
- Cagdas Ermis
- Nicolas Eberz
- Johanna Tiebel
Institutions
- Ruijin Hospital (CN)
- Shanghai Institute of Hematology (CN)
- State Key Laboratory of Medical Genomics
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s11658-025-00777-9
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Technische Universität Dresden