Compact accelerator-based production of carrier-free 177Lu from 18 MeV $$D^+$$ on [176Yb]$$\hbox {Yb}_2\hbox {O}_3$$

The study confirms the feasibility of accelerator-based <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mmultiscripts><mml:mrow></mml:mrow> <mml:mrow></mml:mrow> <mml:mn>177</mml:mn></mml:mmultiscripts> </mml:math> Lu production as an alternative to existing reactor-based methods. The 10 mA, 18 MeV <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mi>D</mml:mi> <mml:mo>+</mml:mo></mml:msup> </mml:math> RFQ-DTL design achieves an exceptionally high <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mmultiscripts><mml:mrow></mml:mrow> <mml:mrow></mml:mrow> <mml:mn>177</mml:mn></mml:mmultiscripts> </mml:math> Lu radiopurity and a competitive overall yield, which can meet the dose requirements of thousands of patients.