DNA methylation regulates TREM1 expression to modulate immune responses and drive progression in colorectal neuroendocrine neoplasm as a potential therapeutic target
Multi-omics analysis suggests that TREM1 may play a role in CrNEN pathogenesis, with potential implications as a therapeutic target. Further validation and research are needed to confirm its clinical relevance and therapeutic potential.
Authors
- Huimin Guo (ORCID: https://orcid.org/0009-0007-0490-2289)
- Qiang Jia (ORCID: https://orcid.org/0000-0001-6689-5255)
- Shuzhan Yao
- Zhaowei Meng (ORCID: https://orcid.org/0000-0002-4478-878X)
- Jia Li (ORCID: https://orcid.org/0000-0002-3422-2125)
- Jian Tan (ORCID: https://orcid.org/0000-0002-2914-0598)
- Guobao Zheng
Institutions
- Tianjin Medical University General Hospital (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1007/s12672-025-03468-1
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tianjin Science and Technology Committee