Two new compounds from the green walnut husks of <i>Juglans mandshurica</i>
Two new compounds (<b>1-2</b>) and thirteen known tetrahydroaphcosterones (<b>3-15</b>) were isolated from the green walnut husks of <i>Juglans mandshurica</i>, with structures elucidated via spectroscopic analyses. Cytotoxicity screening against BGC-823, A-549, and HepG-2 cancer cell lines revealed that compound <b>12</b> inhibited A-549 with the IC<sub>50</sub> value of (54.94 ± 1.72) μM. Compounds <b>3-4</b> and <b>10-12</b> inhibited HepG-2, and the IC<sub>50</sub> values were (62.53 ± 2.52), (51.95 ± 0.65), (63.90 ± 0.30), (66.60 ± 1.35), (61.07 ± 0.31) μM. Compounds <b>4</b> and <b>12</b> inhibited BGC-823 at 60 μM. This study identifies bioactive components and provides a chemical foundation for clinical preparation development.
Authors
- Yuanyuan Zhou (ORCID: https://orcid.org/0000-0002-3684-6126)
- Bing‐You Yang (ORCID: https://orcid.org/0000-0002-2310-2750)
- Xue-Rou Zhang (ORCID: https://orcid.org/0009-0009-7330-9651)
- Yan Liu
- Xiaojuan Zhang (ORCID: https://orcid.org/0000-0002-0971-761X)
- Jie Sun (ORCID: https://orcid.org/0009-0007-7190-0523)
- Zhen-Xing Fang
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- Heilongjiang Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1080/10286020.2025.2547692
- Primary Topic
- Nuts composition and effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Natural Science Foundation of Heilongjiang Province