Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota
We demonstrated that smoking affects the gut immune system by modulating mucosal microbiota. Our findings provide insights into how smoking can have beneficial or detrimental effects on UC or CD, respectively, and may shed light on the reasons why individuals with UC who quit smoking experience disease exacerbation.
Authors
- Shigeo Koido (ORCID: https://orcid.org/0000-0003-0397-4348)
- Takashi Taida (ORCID: https://orcid.org/0000-0002-1870-1863)
- Tamotsu Kato (ORCID: https://orcid.org/0000-0002-8407-4327)
- Nobuo Sasaki (ORCID: https://orcid.org/0000-0002-8798-7244)
- Yumiko Nakanishi
- Toshifumi� Ohkusa (ORCID: https://orcid.org/0000-0002-3029-4201)
- Hiroshi Ohno (ORCID: https://orcid.org/0000-0001-8776-9661)
- Eiji Miyauchi (ORCID: https://orcid.org/0000-0002-8202-684X)
- Nobuhiro Sato (ORCID: https://orcid.org/0000-0002-6960-6567)
- Kan Uchiyama
Institutions
- Chiba University (JP)
- Gunma University (JP)
- Juntendo University (JP)
- Jikei University Kashiwa hospital (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Gut
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1136/gutjnl-2025-334922
- Citations
- 7
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Japan Society for the Promotion of Science