Multiomics and Single-Cell Insights Reveal a Lysophosphatidic Acid–Mediated Resistant Mechanism to Third-generation EGFR-TKI in Non–Small Cell Lung Cancer
Our study highlights the pivotal role of LPA-mediated signaling and metabolic reprogramming in third-generation EGFR-TKI resistance. Targeting LPA production or its downstream pathways may offer novel therapeutic strategies to overcome resistance. This study provides critical metabolic insights for managing EGFR-mutant NSCLC.
Authors
- Xiaohong Han (ORCID: https://orcid.org/0000-0001-9190-0167)
- Ruyun Gao (ORCID: https://orcid.org/0009-0004-3683-8734)
- Le Tang (ORCID: https://orcid.org/0000-0002-5192-3329)
- Mengwei Yang (ORCID: https://orcid.org/0009-0000-0652-6212)
- Sheng Yang (ORCID: https://orcid.org/0000-0003-1630-8037)
- Ning Lou (ORCID: https://orcid.org/0000-0003-0249-1192)
- Guangyu Fan (ORCID: https://orcid.org/0000-0003-1561-0007)
- Jiarui Yao (ORCID: https://orcid.org/0000-0002-9835-395X)
- Yuankai Shi (ORCID: https://orcid.org/0000-0002-8685-6744)
- Liyuan Dai (ORCID: https://orcid.org/0009-0007-4848-3709)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- National Cancer Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0993
- Citations
- 3
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.42